FOXO4

FOXO4

A gene on chromosome Xq13.1, which encodes a member of the O class of winged helix/forkhead transcription factor family, which are regulated by factors involved in growth and differentiation and thus play a role in these processes. It is involved in regulating the insulin signaling pathway, by binding to insulin-response elements and can activate transcription of IGFBP1. It also downregulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes and is involved in negative regulation of the cell cycle
Molecular pathology A translocation of FOXO9 on chromosome X and the homolog of the Drosophila trithorax gene, encodes a DNA binding protein on chromosome 11, which is associated with leukaemia.
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The peptide stops levels of a protein called FOXO4 from increasing in senescent cells - those that remain metabolically active, but lose their ability to replicate and destroy themselves.
When mammalian SIRT1 deacetylates the transcription factor FOXO4 in a NAD-dependent manner, it increases its transactivation process (Kobyashi et al.
It is active in most cells and is very similar to human FOXO1, FOXO3, FOXO4 and FOXO6 genes.