FOXO3

(redirected from FOXO3A)

FOXO3

A gene on chromosome 6q21, which encodes a member of the forkhead family of transcription factors, which is thought to act as a trigger for apoptosis.
   
Molecular pathology
A translocation of FOXO9 with MLL is associated with secondary acute leukaemia.
References in periodicals archive ?
elegans roundworm, one protein in the FOXO family, FOXO3A, seems to protect the worms from all sorts of stress, Willcox said.
Willcox and colleagues analyzed the possible effects of different versions of the FOXO3A gene on the men in the Okinawan study sample.
Proving just what the FOXO3A variant gene really does is complicated.
But Willcox thinks the FOXO3A variant, and dietary measures that mimic the effects of the variant, can help protect human cells against a wide range of sources of stress, just as they can protect roundworm cells against stress.
The gene, FOXO3A, is the second that's been shown to affect life span in people.
If the body were a company, FOXO3A would be a middle manager: It takes instructions from a few "big boss" molecules such as insulin, and in turn directs the activity of hundreds of other genes.
Scientists don't know how the variant of FOXO3A operates to boost longevity.
235) For example, PI3-K/AKT pathway activation by NPM-ALK inhibits FOXO3A (forkhead box O3A), leading to increased cyclin D2 expression and decreased transcription of genes that promote apoptosis [BCL2-like 11 (BIM)] and that negatively regulate the cell cycle (p27).
Kiel scientists have proved that 100-year-old Europeans carry a special sequence variation of the FOXO3A gene.
According to researchers, a variation in the gene FOXO3A has a positive effect on the life expectancy of humans, and is found much more often in people living to 100 and beyond - moreover, this appears to be true worldwide.
We have now eliminated that uncertainty about the connection between FOXO3A and longevity, both by our results from the German sample study and by the support from our French partners in Paris, whose research on French centenarians showed the same trend.
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.