FOXO3

FOXO3

A gene on chromosome 6q21, which encodes a member of the forkhead family of transcription factors, which is thought to act as a trigger for apoptosis.
   
Molecular pathology
A translocation of FOXO9 with MLL is associated with secondary acute leukaemia.
References in periodicals archive ?
They are more likely to carry the FOXO3 gene, that has been proven to increase lifespan in animal tests and is now linked to human height.
Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/ Akt signaling to improve the effects of exercise in elderly rat hearts.
Willcox noted that there is no specific height or age range that should be targeted as a cut-off in the study, in part because "no matter how tall you are, you can still live a healthy lifestyle" to offset having a typical FOXO3 genotype rather than the longevity-enhancing form of the FOXO3 gene.
The researchers showed that shorter men were more likely to have a protective form of the longevity gene, FOXO3, leading to smaller body size during early development and a longer lifespan.
A new study of prostate tumors has shown that a gene, FOXO3, suppresses activation of cells related to immunity and thus leads to a reduced immune response against a growing cancer.
It is active in most cells and is very similar to human FOXO1, FOXO3, FOXO4 and FOXO6 genes.
Castrillon and colleagues have previously shown that the FOXO3 gene is part of the trigger mechanism that results in follicle activation and is an essential negative regulator of this process.
Their findings - which show guys under 5ft 2in live the longest - also indicate shorter men are more likely to have a protective form of the live-longer gene, FOXO3.
Glioma-initiating cell elimi-nation by metformin activation of FOXO3 via AMPK.