FOXO3

FOXO3

A gene on chromosome 6q21, which encodes a member of the forkhead family of transcription factors, which is thought to act as a trigger for apoptosis.
   
Molecular pathology
A translocation of FOXO9 with MLL is associated with secondary acute leukaemia.
References in periodicals archive ?
This is achieved by the E3-ubiquitin ligases regulating transcription of the Forkhead Box (FOXO) proteins, including the FOXO3 isoform (Okamoto et al.
OTCQB: CDXI) and the University of Hawaii said that Cardax's proprietary astaxanthin compound, CDX-085, demonstrated an almost 90% increase in FOXO3 gene expression in mice.
According to a recent study published in the scientific journal Plos One, diminutive males carry the so-called 'longevity gene,' FOXO3, which has been proven to extend the life span of animal test subjects.
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53.
They are more likely to carry the FOXO3 gene, that has been proven to increase lifespan in animal tests and is now linked to human height.
Image: An illustration showing how part of the FOXO3 protein connects with DNA.
Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/ Akt signaling to improve the effects of exercise in elderly rat hearts.
Willcox noted that there is no specific height or age range that should be targeted as a cut-off in the study, in part because "no matter how tall you are, you can still live a healthy lifestyle" to offset having a typical FOXO3 genotype rather than the longevity-enhancing form of the FOXO3 gene.
The researchers showed that shorter men were more likely to have a protective form of the longevity gene, FOXO3, leading to smaller body size during early development and a longer lifespan.
SIRT1 also deacetylates the transcription factors FOXO3 and/or FOXO4, which leads to attenuation of FOXO-induced apoptosis and cell- cycle arrest (Giannakou and Partridge, 2004).