FOXO1

FOXO1

The gene on chromosome 13q14.1 which encodes a forkhead family transcription factor that regulates cell responses to oxidative stress. In the presence of KIRT1, it downregulates cyclin D1 and upregulates CDKN1B as required for cell transition from proliferation to quiescence. It may play a role in myogenic growth and differentiation.

Molecular pathology
FOXO1 translocation with PAX3 has been associated with alveolar rhabdomyosarcoma.
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Children with fusion-negative tumours lack a particular genetic defect often found in rhabdomyosarcoma that results in two genes, called PAX3 and FOXO1, becoming fused together.
The scientists were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells' FOXO1 gene.
The Columbia researchers were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells' FOXO1 gene.
Furthermore the inhibition of miR-182 showed anti-inflammatory properties over the target gene FOXO1.
Oxidative stress drives activated FOXO1 to enter the cell nucleus, suppressing expression of genes involved in glucose metabolism, such as glucose transporter-2 (GLUT2) and pyruvate kinase (7).
The team's research found that KLF6 and FOXO1, both tumor suppressor genes, are turned off as cancer spreads through the body.
1] Nonstandard abbreviations: hepcidinl, mouse hepcidin antimicrobial peptide 1; PGC-1[alpha], peroxisome proliferator-activated receptor [gamma] coactivator 1[alpha]; HNF4[alpha], hepatocyte nuclear factor 4[alpha]; FOXO1, forkhead box O1 protein.
Through experiments in human cells, human lung cancer tissue and mouse lung tissue, the team found that trifluoperazine was able to stop the product of a gene called FOXO1 from being taken out of a tumor cell's nucleus.
The Turkish professor said the research had also shown that boosting XBP1 could lower FOXO1, another protein that causes blood sugar to increase.
It is active in most cells and is very similar to human FOXO1, FOXO3, FOXO4 and FOXO6 genes.
The protein FOXO1 regulates cellular growth and survival pathways in normal cells.
Active Akt signaling functions to inhibit apoptosis through phosphorylation of proapoptotic factors such as BAD [encoded by BCL2-associated agonist of cell death (BAD)], CASP9 [encoded by caspase 9, apoptosis-related cysteine peptidase (CASP9)], and FOXO1 [encoded by forkhead box O1 (FOXO1)].