FOXL2


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FOXL2

A gene on chromosome 3q23 that encodes a member of the forkhead family of transcription factors, which is thought to play a role in ovarian development and function.

Molecular pathology
FOXL2 mutations cause blepharophimosis syndrome and premature ovarian failure 3.
References in periodicals archive ?
Hes et al (12) recently reported the absence of FOXL2 402[right arrow]CrG in 3 testicular aGCTs and 4 incompletely differentiated, testicular, sex cord-stromal tumors.
FOXL2 plays an important role in the ovaries because it is involved in the differentiation of granulosa cells and the maintenance of the ovarian follicle, but it should normally be absent in the testis.
Mutation of FOXL2 in granulosa cell tumors of the ovary.
Aberrant expression of ovary determining gene FOXL2 in the testis and juvenile granulosa cell tumor in children.