FOXL2


Also found in: Dictionary, Thesaurus, Encyclopedia.

FOXL2

A gene on chromosome 3q23 that encodes a member of the forkhead family of transcription factors, which is thought to play a role in ovarian development and function.

Molecular pathology
FOXL2 mutations cause blepharophimosis syndrome and premature ovarian failure 3.
References in periodicals archive ?
202) A negative MART-1 and positive FOXL2 tumor is unlikely to be a steroid cell tumor.
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary.
Mutational analysis of FOXL2 codon 134 in granulosa cell tumour of ovary and other human cancers.
FOXL2 402[right arrow]CrG (C134W) was identified in 40% (2 of 5) of the aGCTs (cases 1 and 3).
Recently, ovarian aGCTs were shown to have a point mutation in FOXL2.
Hes et al (12) recently reported the absence of FOXL2 402[right arrow]CrG in 3 testicular aGCTs and 4 incompletely differentiated, testicular, sex cord-stromal tumors.
FOXL2 plays an important role in the ovaries because it is involved in the differentiation of granulosa cells and the maintenance of the ovarian follicle, but it should normally be absent in the testis.
Aberrant expression of ovary determining gene FOXL2 in the testis and juvenile granulosa cell tumor in children.
Adult-type granulosa cell tumors and FOXL2 mutation.
402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors.