FOXE1

FOXE1

An intronless gene on chromosome 9q22 that encodes a member of the forkhead family of transcription factors, specifically a thyroid transcription factor, which plays a crucial role in thyroid morphogenesis.

Molecular pathology
FOXE1 mutations are linked to congenital hypothyroidism and cleft palate with thyroid dysgenesis.
References in periodicals archive ?
Dr Joost Louwagie (OncoMethylome Sciences, Liege, Belgium) [1] presented this first study that uses the methylation markers SYNE1 and FOXE1 to detect the presence of colorectal cancer.
We optimised the methods of DNA extraction and methylation detection so that we could detect low levels of methylated genes in people with colorectal cance and we were able to find a high frequency of two newly reported methylation genes, SYNE1 and FOXE1, in colorectal cancer patients.
In a minority of these patients, the congenital hypothyroidism is associated with mutations in genes responsible for the development or growth of thyroid follicular cells: thyroid transcription factor 1 (TTF-1; also known as TITF1, NKX2-1, or T/EBP) (3,4), thyroid transcription factor 2 (TTF-2; also known as TITF2, FOXE1, or FKHL15) (5), paired box transcription factor 8 (PAX-8) (6-9), thyrotropin [(TSH).
3 FOXE1 Forkhead box E1 Hypermethylation 9q22 (thyroid transcription factor 2) S100P S100 calcium- Hypomethylation 4p16 binding protein P RARB Retinoic acid Hypermethylation 3p24 receptor, b S100A4 S100 calcium- Hypomethylation 1q21 binding protein A4 CDKN2A/p16 Cyclin-dependent Hypermethylation 9p21 kinase inhibitor 2A MSLN Mesothelin Hypomethylation 16p13.