FOXC1

FOXC1

A gene on chromosome 6p25 that encodes a member of the forkhead family of transcription factors, which plays a role in regulating ocular and embryonic development.

Molecular pathology
FOXC1 mutations are linked to primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly and Axenfeld-Rieger anomaly.
References in periodicals archive ?
28) In addition, Petrini et al (63) showed that frequent copy number loss of FOXC1 is associated with more aggressive tumors and correlates with decreased protein expression.
When they created mice that lack FOXC1 by disabling or "knocking out" the gene that produces this protein, they observed that the animals' hair follicle stem cells spent more time growing hairs and less time in quiescence.
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma," Nature Genetics, vol.
For some transcription factors such as STAT1, AR, HLF, ZEB1, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
7-10] The genes at chromosomes 4q25 and 6p25 have been identified as PITX2 and FOXC1.
ii) Peters syndrome caused by mutations involving PAX6, PITX2, CYP1B1, or FOXC1 genes.
3 AR Corneal opacity PAX6 11p13 AD PITX2 4q25 AD FOXC1 6p25.
Bunlarin baslica ikisi embriyonik gelisimde zaman ve bolge sinirli olarak eksprese edilen iki transkripsiyon faktorunu kodlayan PITX2 (RIEG1) (4q25) ve FOXC1 (6p25) genlerinin mutasyonlaridir.
The gene called FOXC1 is believed to contribute to Dandy-Walker malformation (DWM), a brain defect that occurs in 1 of every 5,000 births.
miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1.
Interplay between PITX2 and FOXC1 explains phenotypic variability and genetic heterogeneity of anterior segment dysgenesis.
5) ARS is a genetically heterogeneous group of abnormalities as a result of mutations in at least four different genetic loci, mutations in PITX2 on ch4q25, FOXC1 on 6p25, PAX6 on 11p13 and FOXO1A on 13q14 have been associated with ARS.