FOXA2

FOXA2

A gene on chromosome 20p11 that encodes a member of the forkhead class of DNA-binding proteins, hepatocyte nuclear factors, which are transcription activators for liver-specific transcripts—e.g., albumin and transthyretin—and interact with chromatin. Homologues in mice have roles in regulating metabolism and differentiation of the pancreas and liver.
References in periodicals archive ?
The "transcription factors" FOXA2 and HNF1A activate a pancreatic enzyme that in healthy people prevents diabetes developing.
Experiments in mice showed that preserving the function of the enzyme affected by FOXA2 and HNF1A blocked the onset of diabetes, even in obese animals.
SEQUENOM reported the results from its discovery genetics program in type II diabetes, including extensive data on FOXA2 (HNF3B), one of eight novel high-confidence diabetes genes that the Company identified in its study.
SEQUENOM reported the results from its discovery genetics program in type 2 diabetes, including extensive data on FOXA2 (HNF3B), one of eight novel high-confidence diabetes genes the Company has identified in its studies.
Andi Braun, SEQUENOM's Chief Medical Officer, included extensive data on FOXA2 (HNF3B), one of several novel high-confidence diabetes genes that the Company has identified in its study.
We have disclosed the identity and genetic findings for FOXA2 to give the scientific community an example of the quality of our findings.