FMR1

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fragile X syndrome

an X-linked recessive syndrome consisting of mental retardation, a characteristic facies, and macroorchidism. DNA analysis shows abnormal trinucleotide repeats on the X chromosome near the end of its long arm, at Xq27.3. Constriction is demonstrable at this site on karyotyping after culture in folate-deficient medium.
See also: Renpenning syndrome.

FMR1

A gene on chromosome Xq27.3 that encodes a protein which binds RNA, is associated with polysomes and may be involved in mRNA trafficking from the nucleus to the cytoplasm.

Molecular pathology
Expansion of the number of trinucleotide (CGG) repeats more than the usual number (up to 53) is associated with fragile X syndrome and a form of premature ovarian failure.

FMR1

Abbreviation for fragile X syndrome.
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Ademas de los titulos anteriores, Post-Doctorado en el Duke University Medical Center (1988 1990), obtuvo en la FMRP el titulo de Profesor Asociado (2011) y el de Profesor Titular (2013), posicion maxima de la carrera universitaria, en regimen de Dedicacion Exclusiva a la Ensenaza e Investigacion.
FMRP associates with polyribosomes as an mRNP, and the 1304N mutation of severe fragile X syndrome abolishes this association.
With iBOLT and eDeveloper, FMRP is able to fully leverage the business process enhancements possible on the IBM System i, which is widely regarded as the most scalable and reliable platform for secure business transactions," said Jack Black, Information Systems Manager for FMRP.
Para este grupo de enfermedades, con repeticiones diferentes a CAG, es mas dificil resumir en pocas palabras el mecanismo de su patogenesis, en FRAXA la repeticion causa la inactivacion del gen por metilacion anormal del promotor, por lo cual no se produce la proteina FMRP, que participa en el transporte de ARNs hacia las dendritas neuronales y en la regulacion de la traduccion del ARN propio y de otros genes (Nolin et al.
The master gene behind the syndrome encodes a protein--called FMRP, for fragile X mental retardation protein--that binds to strands of messenger RNA (mRNA).
FMRP also conducts concurrent oil production from the same formation, and the two extractions are optimized, so production rates are impacted by prices and their effect on overall economics.
Without FMRP, patients exhibit several changes in their brains that underlie the cognitive and behavioral deficits associated with FXS.
Between July 2007 and July 2009, HBV chronically infected patients were recruited from the Hepatitis B Outpatient Clinic of the Clinical Hospital of the Faculty of Medicine of Ribeirao Preto, University of Sao Paulo (HC FMRP USP).
They examined a handful of molecules known to influence RNA dynamics and were surprised to find that the Fragile X syndrome protein called FMRP bound and carried the mRNAs.
Revista da Faculdade de Medicina de Ribeirao Preto e do Hospital das Clinicas da FMRP, Universidade de Sao Paulo.