AFF2

(redirected from FMR2)
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AFF2

A gene on chromosome Xq28 that encodes a putative transcriptional activator of the AF4\FMR2 gene family, which may be involved in alternative splicing regulation.

Molecular pathology
AFF2 is associated with the folate-sensitive fragile X E locus. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation.
References in periodicals archive ?
Although none of the scatterplots was suggestive of a polynomial association between IQ score and FMR2 length, second- and third-order regression models were explored using FSIQ as a continuous dependent variable, and CGG repeat expansion size as the independent variable.
Allelic frequency of the largest ([is greater than] 21 repeats) and the smallest ([is less than] 16 repeats) FMR2 alleles was examined among children with above average (n = 50) vs.
The results support the contention that normal variation in FMR2 gene size does not account for variability in intellectual scores.
The presence of these difficulties may have been associated with other factors, genetic or nongenetic, that may potentially interact with any effects of FMR2 size on intelligence in such a way as to diminish the apparent effect of the latter.
An issue related to ascertainment of the participant sample concerns how representative the present sample is of the general population, with respect to FMR2 allele size.
Allelic frequency differences for FMR2 have been reported elsewhere.
If the FMR2 gene size was associated with variation in intelligence, the degree of association would not be expected to be large, nor would it be expected to work in isolation from other genetic and nongenetic factors.