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A gene on chromosome 16p13.3 of the RetRo gene family that encodes pyrin or marenostrin, an important modulator of innate immunity, which is thought to control the inflammatory response in myelomonocytic cells at the level of the cytoskeleton.

Molecular pathology
Defects in MEFV cause Familial Mediterranean fever, both the autosomal dominant and autosomal recessive forms.


1. Familial Mediterranean fever.
2. Fetal movement felt.
3. Forced mid-expratory flow.
4. Free molecular flow.

Patient discussion about FMF

Q. Can Familial Mediterranean Fever (FMF) cause a heart enlargement? A friend of mine is suffering from FMF. its usually doesn't bother him that much and when it dose the symptoms are stomach ache and fever. he has no heart symptoms and takes no medications. his physician told him that because of the FMF he might suffer from a heart enlargement, and that he should take some oral medications daily to prevent it. how can it be?

A. This question can't be answered with a strict yes or no.
although FMF on its own can't cause heart enlargement, FMF can cause amyloidosis because of the recurrent inflammation. this may lead to enlargement of the heart which is a severe disease.
the good side is that taking medication can decrease the chance of the cardiac enlargement.

More discussions about FMF
References in periodicals archive ?
Mediterranean fever mutations involved in the development of FMF lead to uncontrolled inflammatory response.
Although search of the literature yielded numerous studies involving acute-phase reactants in FMF patients, no long-term study investigating the relationship between gene mutation and acute-phase reactants in attack-free FMF patients was identified.
A clinical diagnosis of FMF was made according to published criteria of Simon et al.
Immunoglobulin light chain levels, ESR and APRs both in active and remission stages in JIA and FMF patients and in healthy controls were measured and are listed in Tables 1 and 2.
First Rhodococcus FMF and Rhodococcus erythropolis IGTS8 were grown at 30 [degrees]C in LB Medium when the cultures density reached 600nm (OD500) of about 2.
I was privileged to be in the meeting when the FMF (familial Mediterranean fever)-MEFV (pyrin) association was first presented (1st International Conference on FMF, Jerusalem, 2007).
The FMF educational activism seems to also imply that their audience was one that did not include people who would already be familiar with the chadari from their own families and cultural experiences.
Art teachers make perfect candidates for selection to the FMF experience.
To obtain FMF approval, PerkinElmer was required to provide clinical data to prove the clinical validity of the assays, to demonstrate a commitment to prenatal screening, and to provide evidence of the successful use of assays in respected international studies.
She was to pay particular attention to the FMF group's use of por/para and ser/estar and was permitted the following feedback options: 1) recasting, 2) clarification request for both meaning and form, 3) explicit feedback by calling direct attention to non-target like productions, and 4) metalinguistic feedback.
We used DNA from patients diagnosed with FMF in our laboratory and samples from carrier relatives and the general population to serve as controls.
Now in its 9th year of existence, FMF sends 600 educators annually to Japan to take part in an educational and cultural study visit.