FLT1


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FLT1

A gene on chromosome 13q12 that encodes a member of the vascular endothelial growth factor receptor (VEGFR) family of receptor tyrosine kinases (RTKs), which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment and a tyrosine kinase (TK) domain within the cytoplasmic domain. FLT1 binds to VEGFR-A, VEGFR-B and placental growth factor, plays an important role in angiogenesis and is expressed in vascular endothelial cells, placental trophoblast cells and monocytes.
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The genes harboring these newly described cancer mutations are KDR, FLT1, and FLT4, which encode receptors for different isoforms of Vascular Endothelial Growth Factor (VEGF); and PDGFRA and PDGFRB, which encode alpha and beta forms of the receptors for Platelet-Derived Growth Factor (PDGF).