HDAC5

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HDAC5

A gene on chromosome 17q21 that encodes histone deacetylase 5; it belongs to class II of the histone deacetylase/acuc/apha family, which has histone deacetylase activity and represses transcription when tethered to a promoter. HDAC5 acts indirectly via myocyte enhancer factor-2 (MEF2 proteins), repressing MEF2-dependent genes.