GFRA1

(redirected from FLJ31546)

GFRA1

A gene on chromosome 10q26.11, that encodes a glial cell line-derived neurotrophic factor, which is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and neurturin, and mediates activation of the RET tyrosine kinase receptor.

Molecular pathology
GFRA1 mutations have been tentatively linked to Hirschsprung disease.