HES1

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HES1

A gene on chromosome 3q28-q29 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family. HES1 is thought to downregulate myogenesis by inhibiting the functions of MYOD1 and ASH1, and may play a role in a functional FA core complex response to DNA cross-link damage.