HDAC6

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HDAC6

A gene on chromosome Xp11.23 that encodes histone deacetylase 6; it belongs to class II of the histone deacetylase/acuc/apha family, which has histone deacetylase activity and represses transcription. HDAC6 plays a key role in degrading misfolded proteins too abundant for chaperone refolding and the ubiquitin-proteasome system by transporting the miscreants to aggresomes, which clear the misfoldizens by autophagy.