CASP8

(redirected from FLICE)

CASP8

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis, as well as various stages of embryological development. CASP8 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is involved in the programmed cell death induced by Fas and various apoptotic stimuli. It is highly expressed in peripheral blood leukocytes and in the spleen, thymus and liver.

Molecular pathology
CASP8 has been detected in the insoluble fraction of affected brain regions in Huntington disease, suggesting a role in neurodegenerative diseases.
References in periodicals archive ?
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
302) However, although apoptosis-inducing genes such as TNF-[alpha] and TNF-related apoptosis-inducing ligand are highly expressed, the cells are likely protected from apoptosis due to expression of the caspase-8 antagonist cFLIP (cellular FLICE inhibitory protein), the caspase inhibitor cIAP2, and the antioxidant enzyme manganese superoxide dismutase.
FLICE inhibitory protein (FLIP) is one of the important antiapoptotic proteins that have been shown to be expressed in many species such as virus, eucaryote, mammal (Carsten et al.
In addition, three latent gene products of HHV8 may play a role in oncogenesis; these include latency-associated nuclear antigen-1, viral cyclin, and viral FLICE inhibitory protein (4).
Three gene products--latency associated nuclear antigen-1, viral cyclin, and viral FLICE inhibitory protein--appear to play an important role and are under investigation (9).