FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
References in periodicals archive ?
FLG Services is a specialist division of A-Plant, which forms part of FTSE 100 company Ashtead Group plc and is the UK's largest equipment rental company with over 185 service centres nationwide, more than 3,600 employees and over 35,000 customers in the construction, industrial, infrastructure and events sectors.
300 infants were tested for the presence of FLG mutations.
3321delA was associated with Chinese AD, and the AD-associated dry skin phenotypes might be good phenotypic indicators of FLG c.
Figure 2(b) displays the C K-edge XANES spectra of FLG and MWCNTs and the reference graphite.
Future studies should investigate whether similar associations appear between FLG mutations and phthalate exposures in other population groups, such as women and children, and whether FLG mutation carriers have greater exposure to other environmental chemicals.
All funds paid into FLG by Dart in respect of exercise of the option will be used to fund the ongoing work program on Liulin during 2011, which is currently being finalised.
These findings show that FLG mutations and cat ownership at birth determine the chances of a child developing eczema during their first year of life, the authors state.
Many FLG practitioners reportedly have died or remain in PRC prisons or other forms of detention.
Individuals named to the FLG benefit from direct access to MITX events, exclusive networking and mentoring opportunities, and engagement with the MITX Board of Directors.
In an Italian study of 100 children with AD and 97 healthy children who served as controls, both clinical and laboratory data showed that FLG gene mutations were linked to early AD onset, a more severe clinical course of disease, and a significantly higher risk of Molluscum contagiosum virus-associated skin infection (Ann Allergy Asthma Immunol.
In addition, recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of FLG gene mutations and concomitant immunoglobulin E sensitization early in life.
Recent studies indicated that Th1/Th2 cytokines influence FLG expression in keratinocytes.