FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
References in periodicals archive ?
Future studies should investigate whether similar associations appear between FLG mutations and phthalate exposures in other population groups, such as women and children, and whether FLG mutation carriers have greater exposure to other environmental chemicals.
All funds paid into FLG by Dart in respect of exercise of the option will be used to fund the ongoing work program on Liulin during 2011, which is currently being finalised.
These findings show that FLG mutations and cat ownership at birth determine the chances of a child developing eczema during their first year of life, the authors state.
This year's FLG Class embodies what our community should represent, and all of the values MITX holds dear," said MITX Board member and FLG Committee Chairman Scott Savitz.
The final group is chosen by the MITX FLG Committee.
The inaugural 2010 FLG - Cort Johnson, Matt Lauzon, Christine Peterson, Ali Robbins Hyatt and Rob Toof - have been a fantastic source of inspiration and insight," said MITX's President, Debi Kleiman.
Pardee, age 68, has over 35 years of financial executive experience and has been a Partner at FLG Partners, LLC, since 2004.
FLG is an "AV" rated law firm, recently recognized as Global Immigration Law Firm of the year for Excellence by Corporate INTL; FLG provides a full range of immigration services for clients in over 80 countries.
Measurement Specialties will support FLG during the next 90 days as we establish our US base of operation and transfer all support functions in China.
The FLG will also have access and exposure to MITX events and education; networking opportunities with MITX members; as well as direct engagement with the MITX Board of Directors, which includes CEOs such as Brian Halligan of HubSpot; Andy Miller of Quattro Wireless; Scott Savitz of Shoebuy.
For all projects under development through the FLG process: an increase by $1 Billion in FLG loan volume; coverage of credit subsidy costs; timely regulatory review and process implementation; and extension of credit at reasonable rates to critical independent, but integral, project components (e.