FOXO1

(redirected from FKHR)
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FOXO1

The gene on chromosome 13q14.1 which encodes a forkhead family transcription factor that regulates cell responses to oxidative stress. In the presence of KIRT1, it downregulates cyclin D1 and upregulates CDKN1B as required for cell transition from proliferation to quiescence. It may play a role in myogenic growth and differentiation.

Molecular pathology
FOXO1 translocation with PAX3 has been associated with alveolar rhabdomyosarcoma.
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References in periodicals archive ?
Two novel phosphorylkation sites on FKHR that are critical for its nuclear exclusion.
La senalizacion por Akt inactiva varios factores proapoptoticos como BAD, procaspasa-9 y factores de trans cripcion FKHR (Forkhead) (Figura 1) (37-38).
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.