FOXO1

(redirected from FKHR)
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FOXO1

The gene on chromosome 13q14.1 which encodes a forkhead family transcription factor that regulates cell responses to oxidative stress. In the presence of KIRT1, it downregulates cyclin D1 and upregulates CDKN1B as required for cell transition from proliferation to quiescence. It may play a role in myogenic growth and differentiation.

Molecular pathology
FOXO1 translocation with PAX3 has been associated with alveolar rhabdomyosarcoma.
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References in periodicals archive ?
Jude researchers found that as myoblasts multiply, most of the FKHR is found in the cytoplasm rather than the nucleus.
In the nucleus of the myoblast, FKHR binds to the DNA, where it activates genes that control the cell's ability to fuse with other myoblasts and form muscles," Grosveld said.
Jude researchers found that FKHR is regulated by one process in most cells, but in a different way in myoblasts.
This normally controls the activity of FKHR and the rate of myoblast fusion.