FGFR4


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FGFR4

A gene on chromosome 5q35.1-qter that encodes fibroblast growth factor receptor-4, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The function of FGFR4 is unknown.

Molecular pathology
FGFR4 is overexpressed in gynaecological tumours, suggesting a role in breast and ovarian malignancies.
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It is well established that the signals evoked by FGF family members are converted by four major FGFRs, namely FGFR1 to FGFR4, to exert myriad biological effects on embryonic development and homeostasis in the adult for a wide range of tissues (14).
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4.
For the FGFR4 SNP rs376618, participants with the TT genotype showed significantly accelerated transit, compared with placebo, in response to both doses of chenodeoxycholate, while only the high dose produced a significant response in those with the TC/CC genotype.
The current results suggest that screening IBS-C patients for common polymorphisms in the FGFR4 and Klotho-beta genes may help preselect the subset of patients who will achieve the best clinical response to chenodeoxycholate pharmacotherapy
The publication reports that an oral dosing of H3B-6527 in mice led to dose-dependent pharmacodynamic modulation of FGFR4 signaling and tumor regression in FGF19 altered HCC xenograft models.
Studies have demonstrated that FGFR4 is a potential therapeutic target and associated with a better therapeutic response, although we observed no association of variants within FGFR4 with any treatment response in our study (19, 20).
Survival tree analysis revealed FGF2, FGFR2, FGFR4, FGF14, and FGF23 gene- gene interactions, indicating FGF2 rs167428 to be the primary factor contributing to overall survival.
Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer.
6] Human genes: FGF2, fibroblast growth factor 2 (basic); FGF1, fibroblast growth factor 1 (acidic); FGF7, fibroblast growth factor 7; FGFR1, fibroblast growth factor receptor1; FGF18, fibroblast growth factor 18; FGF23, fibroblast growth factor 23; FGF5, fibroblast growth factor 5; FGFR2, fibroblast growth factor receptor 2; FGFR4, fibroblast growth factor receptor 4; FGF14, fibroblast growth factor 14; FGF9, fibroblast growth factor 9; FGF10, fibroblast growth factor 10.