FGFR2

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FGFR2

A gene on chromosome 10q25.3-q26 that encodes fibroblast growth factor receptor-3, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR3 mutations are associated with Apert syndrome, Beare-Stevenson cutis gyrata syndrome, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis.
References in periodicals archive ?
FGFR-2 - rejuvenates fibroblast cells to produce new collagen, hyaluronic acid and elastin;
The three polymorphisms used in the study were rs2981582 in FGFR-2 (fibroblast growth factor receptor type 2), rs3803662 near TNRC9 (trinucleotide repeat containing 9), and rs889312 near MAPKKK1 (mitogen-activated protein kinase kinase kinase 1).
FGFR-2 Target Identification and Response Data Also Highlighted; Data Presented at AACR Annual Meeting
Additionally, data assessing Fibroblast Growth Factor Receptor-2 (FGFR-2) response to an FGFR antagonist in a novel FGFR-2 driven model were also highlighted.
AVEO identified FGFR-2 as an important tumor maintenance gene utilizing its proprietary in vivo genetic screen technology.