FGFR


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Prognostic value of FGFR gene amplification in patients with different types of cancer: A systematic review and meta-analysis.
Localization of fibroblast growth factor 2 (FGF-2) protein and the receptors FGFR 1-4 in normal human seminiferous epithelium.
Table 1 Known vertebrate FGF family members and corresponding FGFR interactions Subfamily FGF FGFR specificity FGF 1 FGF 1 1b, 1c, 2b, 2c, 3b, 3c, 4 FGF 2 1b, 1c, 2c, 3c, 4 FGF 4 FGF 4 1c, 2c, 3c, 4 FGF 5 1c, 2c FGF 6 1c, 2c, 4 FGF 7 FGF 3 1b, 2b FGF 7 2b, 4 FGF 10 1b, 2b FGF 22 1b, 2b FGF 8 FGF 8 1c, 2c, 3b, 3c, 4 FGF 17 1c, 2c, 3c, 4 FGF 18 2c, 3c, 4 FGF 9 FGF 9 2c, 3b, 3c FGF 16 2c, 3c FGF 20 1c, 2c, 3b, 3c, 4 FGF 11 FGF 11 No FGFRs FGF 12 No FGFRs FGF 13 No FGFRs FGF 14 No FGFRs FGF 19 FGF 15/19 1c, 2b, 2c, 3b, 3c, 4 FGF 21 1b, 1c, 2b, 2c, 3b, 3c, 4 FGF 23 1c, 2b, 2c, 3b, 3c, 4 Vertebrate FGF family members are listed by subfamily, and interacting FGFR isoforms (i.
The original agreement provided ProChon with an exclusive license to HuCAL- derived antibodies against FGFR 3.
In particular, the agent simultaneously inhibits VEGFR, FGFR and RET, which are especially involved in tumor angiogenesis and proliferation of thyroid cancer.
To analyze the 10 mutations in the FGFR genes, we designed 8 sets of primers (see Table 2 in the online Data Supplement) with the assistance of programs available for free on the Internet [DNA folding server http://frontend.
Dysregulation of FGFR signaling has been implicated in a number of cancers, including squamous non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), gastric, liver, breast, ovarian, endometrial, and bladder carcinomas, fueling significant interest in FGFRs as targets for therapeutic intervention.
BridgeBio has licensed infigratinib (BGJ398), a highly potent and selective inhibitor of the tyrosine kinase receptor FGFR, from Novartis.
Debio 1347 is an orally administered small molecule that selectively targets FGFR 1, 2, 3 signalling pathways.
In addition to VEGFR 1-3 it also inhibits various oncogenic and tumor microenvironment kinases including TIE-2, RAF-1, BRAF, BRAFV600, KIT, RET, PDGFR, and FGFR, which individually and collectively impact upon tumor growth, formation of a stromal microenvironment and disease progression.
We report the rapid and inexpensive detection of FGFR mutations by a relatively novel screening assay, temporal temperature gradient gel electrophoresis (TTGE).