FGF9


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FGF9

A gene on chromosome 13q11-q12 that encodes fibroblast growth factor 9 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF9 is produced mainly by neurons and may be important for glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumours. FGF9 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF9 cause multiple synostoses syndrome type 3.
References in periodicals archive ?
The candidates for such mitogenic mediators are the members of FGF family, such as FGF1, FGF2, FGF9 and FGF18 (6).
En el primero se sometio a estres social a las ratas durante semana y media, posteriormente se observo que sus niveles de FGF9 aumentaron.
El ultimo experimento consistio en la creacion de un virus que interfiere en la produccion del FGF9.
Since FGF9 and 20 are so closely related, Ornitz and Sung-Ho Huh, Ph.
When we examined mice lacking both FGF9 and FGF20, we saw that the embryos had no kidneys," Ornitz said.
More than seven FGFs including FGF1 to FGF5, FGF8 and FGF9 are known to be expressed in the fetal and adult testes (1, 29, 36-38).
Fibroblast growth factor (FGF) 2 and FGF9 mediate mesenchymal epithelial interactions of peritubular and Sertoli cells in the rat testis.
Hence, FGFI, FGF8, and FGF9 are plausible candidate FGFs that could represent the key retinal signal or signals that trigger lens regeneration.
FGF9 has been shown to interact with only FGFR2 and FGFR3, whereas FGFI and FGF8 can activate all four FGFRs (Table 1; Ornitz et al.
Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous 0-catenin.
6] Human genes: FGF2, fibroblast growth factor 2 (basic); FGF1, fibroblast growth factor 1 (acidic); FGF7, fibroblast growth factor 7; FGFR1, fibroblast growth factor receptor1; FGF18, fibroblast growth factor 18; FGF23, fibroblast growth factor 23; FGF5, fibroblast growth factor 5; FGFR2, fibroblast growth factor receptor 2; FGFR4, fibroblast growth factor receptor 4; FGF14, fibroblast growth factor 14; FGF9, fibroblast growth factor 9; FGF10, fibroblast growth factor 10.