FGF8


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FGF8

A gene on chromosome 10q24 that encodes fibroblast growth factor 8 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF8 is expressed in adults only in the testes and ovaries; it is required for normal brain, eye, ear and limb development during embryogenesis, and for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. FGF8 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF8 cause Kallmann syndrome type 6.
References in periodicals archive ?
Keywords: Cerberus protein, Chordin, FGF8 protein, Follistatin, Noggin protein, Somites
So far, there is no confirmation on expression of secretory factors by somite, whether they are able to co-express several neurogenic factors like noggin, chordin, follistatin, cer-berus and FGF8 in vitro.
RT-PCR on somite-derived cells revealed identifiable expression of cerberus, chordin, FGF8, follistatin and noggin after 7 days (Figure 1).
Here, the pattern was different: FGF8 is present in the back part of the jaw, but BMP4 is present along the entire length of the jaw, including where FGF8 is found.
It is not completely understood to what extent Fgf8 regulates the odontogenic potential of the dental epithelium, as Fgf8-/mice lack molars and have developed incisors; it is possible FGF9 rescues the incisor development when FGF8 is not present [Zhang et al.
Pitx2 activates Dlx2, is involved in a positive feedback loop with FGF8, and is required for the regulation and orientation of tooth development [Zhang et al.
19) The FGF8 protein is a member of the fibroblast growth factor family whose members are involved in a variety of biologic processes, including cell growth, morphogenesis, and embryonic development, as well as tissue repair, tumor growth, and invasion.
FGF9 has been shown to interact with only FGFR2 and FGFR3, whereas FGFI and FGF8 can activate all four FGFRs (Table 1; Ornitz et al.
Myxoinflammatory fibroblastic sarcomab Deregulation of FGF8 and NPM3 Myxoid/round cell liposarcoma FUS-DDIT3 EWSR1-DDIT3 Pericytoma with t(7;12) ACTB-GLI1 Solitary fibrous tumor/ Unknown hemangiopericytoma Synovial sarcoma SS18-SSX1 SS18-SSX2 SS18-SSX4 SS18L1-SSX1 Abbreviation: pPNET, peripheral primitive neuroectodermal tumor; ?
Msxl and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.