FGF5

FGF5

A gene on chromosome 4q21 that encodes fibroblast growth factor 5 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF5 is required for regulating hair growth, inhibiting hair elongation by promoting progression from anagen (the growth phase of the hair follicle) into catagen (the apoptosis-induced regression phase). FGF5 interacts with FGF receptors FGFR1 and -2.
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More than seven FGFs including FGF1 to FGF5, FGF8 and FGF9 are known to be expressed in the fetal and adult testes (1, 29, 36-38).
98) under the additive model, and FGF5 (fibroblast growth factor 5) rs3733336 (OR, 0.
We also identified that 4 SNPs (FGF18 rs3806929, FGF7 rs9920722, FGF23 rs12812339, and FGF5 rs3733336) were significantly associated with improved response to treatment.
6] Human genes: FGF2, fibroblast growth factor 2 (basic); FGF1, fibroblast growth factor 1 (acidic); FGF7, fibroblast growth factor 7; FGFR1, fibroblast growth factor receptor1; FGF18, fibroblast growth factor 18; FGF23, fibroblast growth factor 23; FGF5, fibroblast growth factor 5; FGFR2, fibroblast growth factor receptor 2; FGFR4, fibroblast growth factor receptor 4; FGF14, fibroblast growth factor 14; FGF9, fibroblast growth factor 9; FGF10, fibroblast growth factor 10.
The study showed that combinations of various forms of only three genes - named RSPO2, FGF5 and KRT71 - account for seven major coat types in purebred dogs.
They also found that FGF5 is linked to whether a dog's fur is long or short and KRT71 determines if the hair is curly or wavy.