FGF4


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FGF4

A gene on chromosome 11q13.3 that encodes fibroblast growth factor 4 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF4 is required for normal limb and cardiac valve development during embryogenesis. It interacts with FGF receptors FGFR1, -2, -3 and -4.
References in periodicals archive ?
2002) used an in vitro method of culturing newt dorsal iris cell reaggregates and established that FGF2 and FGF4 were able to induce lens formation in these cultures.
In case of short-legged dogs, the inserted retrogene results in the overproduction of the FGF4 protein, which according to researchers could turn on key growth receptors at the wrong times during foetal development.