FGF4


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FGF4

A gene on chromosome 11q13.3 that encodes fibroblast growth factor 4 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF4 is required for normal limb and cardiac valve development during embryogenesis. It interacts with FGF receptors FGFR1, -2, -3 and -4.
References in periodicals archive ?
5 142 CDKN1C (p57) 36 TSG 11q13 147 CCND1 27 Amp 11q13 148 FGF4, FGF3 36 Amp 12p tel 157 8M16/SP6 20 Sub Tel 12q13 163 CDK2, ERBB3 27 Amp 13q tel 174 D13S327 27 Sub Tel 14q32.
The AGENT trial, which evaluated the effects of ascending doses of adenoviral-mediated human FGF4 gene transfer in patients with stable exertional angina, had two objectives: (1) to evaluate safety and anti-ischemic effects of ascending doses of adenovirus mediated FGF4 gene transfer in patients with stable exertional angina, and (2) to select potentially safe and effective dose(s) for subsequent study.
Ad5-FGF4 is used in this release as a generic term for a product candidate consisting of a human replication-deficient serotype 5 adenovirus in which the E1A/E1B genes are replaced by the human FGF4 gene driven by a CMV promoter.