FGF3


Also found in: Acronyms.

FGF3

A gene on chromosome 11q13 that encodes fibroblast growth factor 3 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF3 may be required for normal ear development. It interacts with FGF receptors FGFR1 and -2.
 
Molecular pathology
FGF3 mutations are a cause of deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
References in periodicals archive ?
Cbfa1/Runx2 protein is a critical transcriptional regulator of osteoblast differentiation that is down-regulated by Msx1 most likely via FGF3 [Zhang et al.
stage 48-51) and have not been able to detect FGF3 and FGF20.
5 142 CDKN1C (p57) 36 TSG 11q13 147 CCND1 27 Amp 11q13 148 FGF4, FGF3 36 Amp 12p tel 157 8M16/SP6 20 Sub Tel 12q13 163 CDK2, ERBB3 27 Amp 13q tel 174 D13S327 27 Sub Tel 14q32.