FGF2


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FGF2

A gene on chromosome 4q26 that encodes fibroblast growth factor 2 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration. FGF2 plays a key role in various processes, including limb and nervous system development, wound healing and tumour growth, as well as angiogenesis. It is expressed in normal ovarian tissue and in hepatocellular carcinoma, but not in normal liver cells. FGF2 interacts with FGF receptors FGFR1, -2, -3 and -4.
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An early study observed that the FGF2 and FGFR1 genes are highly expressed in human ovarian tumor endothelium (37).
Following this finding, the researchers attempted to inhibit FGF2 in old muscles to prevent the stem cell pool from being kick-started into action unnecessarily.
Bu hucrelerin terapotik potansiyelleri, kulturu yapilmis kok hucrelerin transplantasyonu yapilarak ya da EGF ve FGF2 gibi eksojen buyume faktorleri ile endojen kok hucrelerin stimulasyonu ile anlasilabilir (21).
While encourageing stem cells to divide and repair muscle is a normal and crucial process, they found that FGF2 could also awaken the dormant pool of stem cells even when they were not needed.
Inhibitors of growth factors FGF2 and VEGF for breast cancer 316
Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
Molecules involved in the communication between the microenvironment and the epithelial cells include EGF, FGF2, FGF10, HGF, fibroblast secreted protein, transforming growth factor [beta] (Bhowmick et al.
We developed a dual fluorescent PSA/FGF2EPISPOT to characterize PSA-SCs for the secretion of FGF2 and applied it to blood samples from 19 patients with localized prostate cancer.
Working with his other advisor, MIT Professor of Biological Engineering Ram Sasisekharan, Berry and his colleagues conceived the idea of a new protein called dimeric FGF2, or dFGF2 for short.
In the study, researchers examined FGF2 levels in rats selectively bred for high or low anxiety for over 19 generations.