FGF2


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FGF2

A gene on chromosome 4q26 that encodes fibroblast growth factor 2 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration. FGF2 plays a key role in various processes, including limb and nervous system development, wound healing and tumour growth, as well as angiogenesis. It is expressed in normal ovarian tissue and in hepatocellular carcinoma, but not in normal liver cells. FGF2 interacts with FGF receptors FGFR1, -2, -3 and -4.
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Bernard indicated that she is already looking at identifying new anti-cancer compounds in her research that could stop the effects of FGF2.
To confirm if the gene products are associated with transition of the endometrium to refractory in vivo, recombinant FGF2 and FGF9 proteins (rFGF2 and rFGF9, respectively) were administered to DI mice and LE cell proliferation was analyzed after administration.
Although the neuro-protective effect of FGF2 is well understood, its effect on neonatal hypoxic-ischaemic brain injury (HIBI) has not been adequately investigated.
An early study observed that the FGF2 and FGFR1 genes are highly expressed in human ovarian tumor endothelium (37).
The FGF2 involvement is interesting, because FGF2 deficiency is associated with depressive-like behaviors in animals and is linked to depression in humans," McEwen said.
The scientists found a drug that inhibits FGF2 prevented the decline of muscle stem cells.
2010), and cryopreserved large batches after an additional phase of NC amplification in medium containing EGF and FGF2 (Figure 1A).
Specifically, FGF2 appears to be necessary for lens regeneration in the newt (McDevitt et al.
Los principales factores de crecimiento angiogenicos a ser considerados son el VEGF y el FGF2 (factor de crecimiento de fibroblastos), los cuales son potentes estimulantes de la proliferacion de las celulas endoteliales y de la migracion (16, 17).
Inhibition of LH-stimulated androgen production in rat immature Leydig cells: Effects on nuclear receptor steroidogenic factor 1 by FGF2," Growth Factors 28(1): 1-9.