FGF1


Also found in: Acronyms.

FGF1

A gene on chromosome 5q31 that encodes fibroblast growth factor 1 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF1 interacts with FGF receptors FGFR1, -2, -3 and -4.
References in periodicals archive ?
The mechanism of FGF1 still isn't fully understood nor is the mechanism of insulin resistance but the researchers discovered that the protein's ability to stimulate growth was independent of its effect on glucose, bringing the protein a step closer to therapeutic use.
Dr Michael Downes writes in US medical journal Nature: "Many previous studies that injected FGF1 showed no effect on healthy mice.
FGF1 offers a new method of controlling it in a powerful and unexpected way.
Injecting a protein called FGF1 restores the body's normal response to insulin, keeping blood sugar at a lower level for up to two days
US researchers found FGF1 had no side effects at all on diabetic mice, although this has not yet been tested in humans
Injections of protein FGF1 also did not cause blood sugar levels to drop so low that the diabetic risked hypoglycaemia
In the first three patients enrolled in the trial, FGF1 did, in fact, lead to new vessel formation and can be seen as a "blush" during cardiac catheterization.
The use of the FGF1 growth factor protein may also have significant application in the treatment of stroke or other problems consisting of decreased blood flow to the brain, or in peripheral vascular disease when there is diminished blood flow to the legs.
The first split on the decision tree was FGF1 rs7727832, indicating that this SNP was the primary risk factor for ovarian cancer in the study population.
One SNP (FGF1 rs17099029) associated with survival was in cis eQTL with FGF1 expression (P = 0.
In particular, FGF1 rs7727832 showed the most significant association with ovarian cancer in the main-effect analysis, and this result was supported by the CART gene-gene interactions analysis.
Previous studies have indicated that FGF1 overexpression may lead to increased angiogenesis, leading to poorer overall patient survival (23), and a recent study demonstrated that FGF1 expression adversely influenced survival in patients with ovarian tumors (24).