FGF8

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FGF8

A gene on chromosome 10q24 that encodes fibroblast growth factor 8 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF8 is expressed in adults only in the testes and ovaries; it is required for normal brain, eye, ear and limb development during embryogenesis, and for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. FGF8 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF8 cause Kallmann syndrome type 6.