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The Generx FGF-4 transgene has been engineered to include a signal peptide, which enables effective secretion from cells that express the protein (such as cardiac myocytes).
The substance of AGT-MI, Ad5FGF-4, is an adenoviral vector that has been designed to transport the gene that encodes for the growth factor FGF-4 into cells of the heart, leading to the formation of new small blood vessels (angiogenesis).
In the Phase II/III trial, patients will randomly receive either FGF-4 or a placebo via a one-time intracoronary injection by heart catheterization.
It has been shown in preclinical and in early Phase I and II patient studies that FGF-4 helps the vessels to grow faster, decreases angina, and reduces ischemia.
A dual recombinant which combined an FGF-4 gene and a VEGF-145 gene has been shown to be associated with a favorable treatment effect in an animal model of coronary artery disease.
This collaboration has now been broadened to include the study of additional forms of FGF-4 and their interaction with biological receptors.
This research program builds upon previous work with the FGF-4 gene, and will also help to identify additional types of angiogenic genes having potentially unique biological properties as we look forward to the development of next generation products," said Christopher J.
In fact, a dual recombinant that combined a VEGF-145 gene and an FGF-4 gene was recently shown to be associated with a favorable treatment effect in an animal model of coronary artery disease.
The company's portfolio includes numerous human genes in the Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) families including FGF-4, FGF-4f, VEGF-145, VEGF-145-I, VEGF-145-II, VEGF-145-III, VEGF-138 and others.
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- FGF receptor
- FGF-inducible kinase