FGF10

(redirected from FGF-10)

FGF10

A gene on chromosome 5p13-p12 that encodes fibroblast growth factor 10 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. Its name notwithstanding, FGF10 is mitogenic for keratinocytes but has little effect on fibroblasts; FGF10 interacts with FGF receptors FGFR1 and -2.

Molecular pathology
Defects in FGF10 cause autosomal dominant aplasia of lacrimal and salivary glands and lacrimo-auriculo-dento-digital syndrome (LADDS).
References in periodicals archive ?
Therefore, lack of FGF-7 and FGF-10 has consistently led to retarded epithelial growth in thymus19.
Since the neural crest migration and subsequent infiltration of pharyngeal mesenchyme was arrested, probably, less than optimum levels FGF-7 and FGF-10 failed to induce the proliferation of ERC's in thymus.
sup][22] The activation of lung stromal cells mediated by TGF-[sz] suppresses their epithelial-supportive capacity via the downregulation of epithelial growth factors such as FGF-10.
TGF-[sz] signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.
No increase in proliferation was found after exposure to FGF-10, FGF-1 and heparin sulfate.