FGFR2

(redirected from FGF receptor)

FGFR2

A gene on chromosome 10q25.3-q26 that encodes fibroblast growth factor receptor-3, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR3 mutations are associated with Apert syndrome, Beare-Stevenson cutis gyrata syndrome, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis.
References in periodicals archive ?
The levels of [sz]-Klotho and FGF receptor 1 (FGFR1) protein were measured by enzyme-linked immunosorbent assay (ELISA).
Dusterhoft and colleagues studied FGF and FGF receptor expression in low-frequency stimulated rat muscles and rat satellite cell cultures [25].
a cancer drug development company that he co-founded in 2008, where he led the clinical development of the anti-angiogenic drug candidate telatinib for patients with advanced stomach cancer, as well as advancing a novel FGF receptor kinase inhibitor for first-in-man clinical studies.
In another study, expression of FGF2 and FGFR3 (also named PFR3, or Pleurodeles homolog of FGF receptor 3) specifically seemed to be correlated with Wolffian lens regeneration (McDevitt et al.
Expression of messenger ribonucleic acids encoding for basic fibroblast growth factor (FGF) and alternatively spliced FGF receptor in human fetal ovary and uterus.
The cocktails include inhibitors of GSK3, MEK, and FGF receptor tyrosine kinases.
This potent mitogenic factor requires the presence of heparan sulfate (as found on syndecans) as coreceptors for FGF receptor binding and signaling (Bernfield & Hooper 1991; Mundhenke et al.
Of the two FGF receptor genes for which we found significant changes, fgfr1 is only weakly expressed in the developing brain but probably serves as an organization factor (Blak et al.
The conjugates contain a polypeptide that is reactive with an FGF receptor, such as bFGF, or another heparin-binding growth factor, cytokine, or growth factor coupled to a nucleic acid binding domain.
This is explained by the very low expression of the FGF receptor 1 and the coreceptor Klotho in uremic parathyroid glands, which results in resistance to the inhibitory stimuli of FGF-23 (20).
ACTB1003 inhibits cancer cell growth by targeting the FGF receptor family, which are mutated in a number of human cancer types.