FGFR2

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FGFR2

A gene on chromosome 10q25.3-q26 that encodes fibroblast growth factor receptor-3, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR3 mutations are associated with Apert syndrome, Beare-Stevenson cutis gyrata syndrome, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis.
References in periodicals archive ?
Dusterhoft and colleagues studied FGF and FGF receptor expression in low-frequency stimulated rat muscles and rat satellite cell cultures [25].
Expression of messenger ribonucleic acids encoding for basic fibroblast growth factor (FGF) and alternatively spliced FGF receptor in human fetal ovary and uterus.
The cocktails include inhibitors of GSK3, MEK, and FGF receptor tyrosine kinases.
This potent mitogenic factor requires the presence of heparan sulfate (as found on syndecans) as coreceptors for FGF receptor binding and signaling (Bernfield & Hooper 1991; Mundhenke et al.
Of the two FGF receptor genes for which we found significant changes, fgfr1 is only weakly expressed in the developing brain but probably serves as an organization factor (Blak et al.
The conjugates contain a polypeptide that is reactive with an FGF receptor, such as bFGF, or another heparin-binding growth factor, cytokine, or growth factor coupled to a nucleic acid binding domain.
This is explained by the very low expression of the FGF receptor 1 and the coreceptor Klotho in uremic parathyroid glands, which results in resistance to the inhibitory stimuli of FGF-23 (20).
Additionally, the level of FGF released by the muscle and its effect on satellite cell proliferation is proportional to the expression of FGF receptor (Sheehan and Allen, 1999).
Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer.
ACTB1003 inhibits cancer cell growth by targeting the FGF receptor family, which are mutated in a number of human cancer types.
The report includes a compilation of current active projects in research and development of molecules targeting FGF or the FGF receptor.