NLRP3

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NLRP3

A gene located on chromosome 1q44 that encodes a pyrin-like protein that interacts with the apoptosis-associated speck-like protein PYCARD/ASC. NLRP3 has a caspase recruitment domain, and belongs to the NALP3 inflammasome complex; it plays a role in regulating inflammation and apoptosis.
 
Molecular pathology
NLRP3 mutations are associated with chronic infantile neurological cutaneous and articular (CINCA) syndrome, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease (NOMID).
References in periodicals archive ?
In addition, the integration of Latens FCAS with the Amino set-top boxes and PVR's, widens the choice for all IPTV operators to offer advanced services in order to better compete in the market place.
The FCAS approach to security is unique in many ways, with pre-emption of piracy a particular advantage over other CA solutions.
June 13, 2012 /PRNewswire/ -- EagleEye Analytics, the leading provider of world class predictive analytics solutions to the property and casualty insurance industry, announced today that it has appointed Mary Hennessy, FCAS, as Vice Chair of its Board of Directors.
John Beckman, FCAS, MAAA, SVP & Chief Risk Officer at CNA Insurance, will examine best practices for integrating ERM into strategic planning.
Ross, CPCU, ARe, FCAS, MAAA - Corporate Actuarial Kathryn L.
Brian Brown , FCAS, MAAA, Milliman principal and consulting actuary
Michael Schmitz , FCAS, MAAA, Milliman principal and consulting actuary
The inaugural meeting was held on April 26, 2011 at Century Insurance Group in Westerville, Ohio and was facilitated by Nathan Voorhis, FCAS, MAAA, Senior Vice President of General Agency Group at Century.
On November 5th, Laurent Collet-Billon, head of the French defence procurement agency (DGA), and Bernard Gray, Chief of Defence Materiel at the UK Ministry of Defence, launched the feasibility phase of the FCAS (Future Combat Air System) programme to carry out the system definition of an Anglo-French remotely-piloted combat aircraft.
As part of the feasibility phase, Finmeccanica Selex ES and Thales have been awarded contracts to lead, specify and define the FCAS s multifunction sensor suite and communications sub-systems.
In-house and judicial speakers confirmed to date include: Jennifer Biggs, FCAS, MAAA, Director, Towers Watson; Hon.
Receiving this inaugural award is a great honor for AIR in that it recognizes the hard work and exceptional customer service provided by our cross-functional team of scientists, analysts and consultants," said David Lalonde, FCAS, FCIA, MAAA, senior vice president at AIR Worldwide.