FBLN2

FBLN2

A gene on chromosome 3p25.1 that encodes fibulin-2, a secreted glycoprotein of the fibulin family that binds various extracellular ligands and calcium and plays a key role during organogenesis, especially during the differentiation of the heart, muscle and brain.
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q-RT-PCR analysis of 5 of the 11 most upregulated genes (FBLN1, VWF, FBLN2, MMP2, and LEP) showed that 3 genes, FBLN1, VWF, and FBLN2, were significantly upregulated (Table 2).
12] Human genes: VWF, von Willebrand factor; LEP, leptin; MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); FBLN1, fibulin 1; FBLN2, fibulin 2; ACTS, actin, beta; CRISPLD2, Cysteine-rich secretory protein LCCL domain containing 2; SERPINF1, Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; ITM2A, Integral membrane protein 2A; LEPR, leptin receptor; ZFP36L2, zinc finger protein 36, C3H type-like 2; ELN, elastin.