FBLN1

FBLN1

A gene on chromosome 22q13.31 that encodes fibulin-1, a secreted glycoprotein incorporated into a fibrillar extracellular matrix by laminin and nidogen binding. Fibulin is involved in cell adhesion and migration along protein fibres within the ECM; it may be critical for development and contribute to the ECM supramolecular organisation, especially of basement membranes. It has been implicated in cell transformation and tumour invasion, and may be a tumour suppressor; it plays a role in haemostasis and thrombosis by binding fibrinogen and incorporating itself into blood clots. It may also modulate the neurotrophic activities of APP, especially soluble APP.
References in periodicals archive ?
Among the upregulated genes, FBLN1 displayed the highest level of fold change.
12] Human genes: VWF, von Willebrand factor; LEP, leptin; MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); FBLN1, fibulin 1; FBLN2, fibulin 2; ACTS, actin, beta; CRISPLD2, Cysteine-rich secretory protein LCCL domain containing 2; SERPINF1, Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; ITM2A, Integral membrane protein 2A; LEPR, leptin receptor; ZFP36L2, zinc finger protein 36, C3H type-like 2; ELN, elastin.