FBLN1

(redirected from FBLN)
Also found in: Acronyms.

FBLN1

A gene on chromosome 22q13.31 that encodes fibulin-1, a secreted glycoprotein incorporated into a fibrillar extracellular matrix by laminin and nidogen binding. Fibulin is involved in cell adhesion and migration along protein fibres within the ECM; it may be critical for development and contribute to the ECM supramolecular organisation, especially of basement membranes. It has been implicated in cell transformation and tumour invasion, and may be a tumour suppressor; it plays a role in haemostasis and thrombosis by binding fibrinogen and incorporating itself into blood clots. It may also modulate the neurotrophic activities of APP, especially soluble APP.