CXCR4

(redirected from FB22)
Also found in: Wikipedia.

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
References in periodicals archive ?
Tenders are invited for 20 New Faculty Apartments: FC1, FC2, FC3, FC4, FC9, FC10, FC11, FC12, FC13, FC14, FC15, FC16, FC17, FC18, FC19, FC20, FB22, FB23, FD03 and FD04.
African Copper Twin Results Falconbridge Results Selected From To Cu% Length From To Cu% Length Package (m) (m) (m) (m) T1FB22 FB22 A 222.