ADH5

(redirected from FALDH)

ADH5

A gene on chromosome 4q23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. ADH5 has minimal activity for ethanol oxidation, but has a high activity for oxidation of long-chain aliphatic alcohols and oxidation of S-(hydroxymethyl) glutathione. The ADH5 protein product is critical in metabolic elimination of formaldehyde, a potent irritant and sensitising agent that causes lacrymation, rhinitis, pharyngitis and contact dermatitis.
References in periodicals archive ?
However, very little was known about the precise mechanism of the conversion of phytol to phytanic acid until our discovery of the involvement of FALDH in this pathway.
The FALDH-deficient fibroblasts were from established SLS patients as concluded from the clinical history, deficient FALDH activity, and distinct mutations in the ALDH10 gene (11).
When we assessed FALDH activity by measuring production of NADH fluorometrically (3), we observed high residual background activity in fibroblasts derived from SLS patients with nonsense mutations in ALDH10.