FABP4

FABP4

A gene on chromosome 8q21 that encodes a lipid transport protein in adipocytes which plays a role in intracellular transport of long-chain fatty acids and retinoic acids, delivering them to their cognate receptors in the nucleus.
References in periodicals archive ?
FABP4 predicts atherogenic dyslipidemia development.
The dual-effect risk loci also include the region covering the gene FABP4, which is already being investigated for its potential as a diabetes and heart-disease drug target.
Effects of FM550, IPTP, and TPP on FABP4 Protein Expression in the Presence of Dexamethasone
2D-DIGE, Se sometio a individuos (72) MALDI-TOF/TOF obesos y con sobrepeso a restriccion calorica por 5 semanas, las muestras de tejido adiposo subcutaneo abdominal antes y despues de la intervencion tuvieron diferencias en los niveles de expresion de las proteinas ApoAl, tubulina [beta]5, anexina A2, la proteina antioxidante 1(AOP1), FABP4 y vimentina.
We used Herbalog as a screening tool and identified labdane diterpenoids from Andrographis paniculata as leading candidates of FABP4 inhibitors.
They have found a protein called FABP4 (fatty acid binding protein 4) could be a characteristic of pre-eclampsia in women with Type 1 diabetes.
Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese Black cattle.
Both intracellular lipid droplet formation and expressions of adipogenic genes including PPARy, C/EBPa, FABP4 and LPL, which were inhibited by SH21B, were significantly recovered by (3-catenin siRNA transfection.
FABP4 is produced by adipocytes and macrophages during their differentiation and intracellular lipid accumulation (6-10).
Results demonstrated that FABP4, CST2, and COLEC12 were over-regulated and that FAT1 and MGP were under-regulated in hypertensive compared with normotensive by qRT-PCR.
When the researchers compared primary ovarian cancer tissue with ovarian cancer tissue, which had spread to the omentum, they found that tumour cells next to omental fat cells produced high levels of FABP4.