FABP4

FABP4

A gene on chromosome 8q21 that encodes a lipid transport protein in adipocytes which plays a role in intracellular transport of long-chain fatty acids and retinoic acids, delivering them to their cognate receptors in the nucleus.
References in periodicals archive ?
PPARG and FABP4 are reportedly key regulators in the PPAR signaling pathway associated with adipogenesis and marbling traits in beef cattle.
When the researchers compared primary ovarian cancer tissue with ovarian cancer tissue, which had spread to the omentum, they found that tumour cells next to omental fat cells produced high levels of FABP4.
Both intracellular lipid droplet formation and expressions of adipogenic genes including PPARy, C/EBPa, FABP4 and LPL, which were inhibited by SH21B, were significantly recovered by (3-catenin siRNA transfection.
FABP4 is produced by adipocytes and macrophages during their differentiation and intracellular lipid accumulation (6-10).
FABP4 plasma levels are increased in familial combined hyperlipidemia.
Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages.
Expression levels of FABP4 and SCD were not significantly different after 2 or 4 days, respectively.
mRNA and protein levels of fatty acid synthase and FABP4 were inhibited by CE and RBP4, and CD36 protein levels were also decreased by CE.
Our recent studies showed that PPARG and FABP4 gene expression is associated with IMF deposition in Korean cattle (Jeong et al.
gov/genbank/)], mouse FABP4 (fatty acid binding protein 4; NM_024406), mouse 18S RNA (NR_003278), rat AOX (acyl co-A oxidase; NM_017340), and rat 18S/28S RNA (M11188).
Identification of the SNP (single nucleotide polymorphism) for fatty acid composition associated with beef flavor-related FABP4 (fatty acid binding protein 4) in Korean cattle.