F2RL2

F2RL2

A gene on chromosome 5q13 that encodes a member of the protease-activated receptors (PARs), which belong to the G protein-coupled cell surface receptor family. F2RL2 is a co-factor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4, and plays an essential role in hemostasis and thrombosis.
References in periodicals archive ?
Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1).
HPAEC were treated for 4 hr (0, 1, 10, and 100 [micro]g/mL UFP) for F3 Q-PCR analysis or 2 and 24 hr (0, 25, and 100 [micro]g/mL water-soluble and -insoluble UFP fractions) for all F3, F2RL2, F8A1, and HMOX1.
The water-soluble fraction tended to increase the expression of F2RL2 (Figure 2B).
Among these were genes related to the coagulation-inflammation circuitry, including up-regulation of F3, F2RL2, IL-6, and IL-8 and downregulation of F8A1.