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extrinsic pathway |
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Extrinsic pathway One of three pathways in the coagulation cascade. Mentioned in: Partial Thromboplastin Time extrinsic of external origin. extrinsic allergic alveolitis see hypersensitivity pneumonitis. extrinsic factor see extrinsic factor. extrinsic incubation period the period between infection of the arthropod insect vector and the vector's ability to infect the next vertebrate host. extrinsic pathway see coagulation pathways. extrinsic protein see membrane proteins. extrinsic pathway Hematology The arm of coagulation activation which, like the intrinsic pathway, converges on the common pathway, ie factor X activation; the EP is activated by exposure of blood to tissue factor, circulating factor VII, Ca2+
and phospholipid. Cf Common pathway, Intrinsic pathway. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases. The extrinsic pathway is initiated by tissue damage and is primarily responsible for the desired clotting that occurs at the site of injury, limiting blood loss. |
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