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However, Didriksen and Christensen (1993) argued that the suppression of schedule-induced polydipsia by dopamine blockers is not due to the induction of extrapyramidal side effects, because that suppression was not antagonized by scopolamine (an anticholinergic drug used to counteract neuroleptic-induced dystonia) or by diazepam (a benzodiazepine used to counteract akathisia).
No significant effects were observed on extrapyramidal side effects, other than akathisia, or on plasma prolactin levels.
9) The dose threshold for extrapyramidal side effects was highly variable in the above studies, making a cut-off of appropriate metoclopramide dosing very difficult.
These drugs have a tendency to produce fewer extrapyramidal side effects while treating more of the negative symptoms of schizophrenia.
advantage is that the type of extrapyramidal side effects seen with droperidol tends to be akathisia, 'which is common, but I have never seen a dystonic reaction.
Among the most serious are extrapyramidal side effects (EPS), which include dystonic reactions, akathisia, and parkinsonism.
The study also looked at extrapyramidal side effects for those exposed to trimethobenzamide.
She received haloperidol, a drug primarily cleared through the 2D6 pathway that "also has one of the highest frequencies; of extrapyramidal side effects.
I reasoned that if the newer antipsychotics indeed were less likely to cause acute, parkinsonian or extrapyramidal side effects, then TD would be virtually eradicated.
Adult patients presenting to the emergency department at Monte-fiore Medical Center in New York with acute migraine were randomized to receive one of the three doses of metoclopramide in an IV infusion over 20 minutes coadministered with 25 mg diphenhydramine to prevent the development of extrapyramidal side effects such as akathisia.
In preclinical studies, they do not induce secondary negative symptoms, extrapyramidal side effects (physical symptoms that can occur in individuals taking antipsychotic medications) or neuroendocrine disturbances associated with current agents.
Background & objectives: Use of typical antipsychotics like haloperiflol in treatment of schizophrenia is associated with a high incidence of extrapyramidal side effects.

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