extracellular matrix

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extracellular matrix

the aggregate of proteins secreted by cells.

extracellular matrix

a substance containing collagen, elastin, proteoglycans, glycosaminoglycans, and fluid, produced by cells and in which the cells are embedded. The matrix secreted by chondroblasts, for example, is responsible for the properties of cartilage.

extracellular matrix

Non-living material secreted by cells that fills spaces between the cells in a tissue, protecting them and helping to hold them together. The extracellular matrix may be semifluid or rigidly solid and hard as in bone. It is composed mainly of protein and includes collagens, elastin, reticulin, glycoproteins, proteoglycans, fibronectin, laminins and osteopontin.

extracellular matrix (ECM)


extracellular matrix (eksˈ·tr·selˑ·y·ler māˑ·triks),

n substance produced by cells and secreted into the environment in which the cells are embedded; contains collagen, proteoglycans, glycosaminoglycans, and fluid; can influence the behavior of the cells. Also called
ECM. See also connective tissue.


situated or occurring outside a cell or cells.

extracellular constituents
all of the constituents of the body outside the cells; include water, electrolytes, protein, glucose, enzymes, hormones.
extracellular fluid
all of the body fluid lying outside the cells. Includes intravascular fluid or plasma and the interstitial fluid. That part of the extracellular fluid that is in special cavities which have special characteristics, e.g. synovial fluid, urine, aqueous humor of eye, are called transcellular fluids.
extracellular matrix
the network of proteins and carbohydrates that surround a cell or fill the intercellular spaces.
extracellular space
References in periodicals archive ?
Brooks has pioneered research into the role of extracellular matrix proteins in the angiogenesis cascade.
a biotechnology company developing antagonists to extracellular matrix proteins, today announced the publication of data confirming the anti-tumor effects of its lead antibody therapeutic.
The fibrotic scar tissue is made up of extracellular matrix proteins such as type I collagen, proteoglycans and fibronectin.
12 months following treatment, discs that received ADRCs in hyaluronic acid (HA) carrier compared to discs treated with HA only demonstrated significantly greater levels of the disc specific extracellular matrix proteins, aggrecan and type II collagen.
Initially, PRIME-XV[TM] products will comprise of a serum-free medium for the expansion of human mesenchymal stromal/ stem cells (MSCs), biopreservation solutions and extracellular matrix proteins.
However, when EpiFix is applied to the chronic wound, the inflammation is modulated, and then our tissue helps multiple cell types, like endothelial and dermal fibroblast cells, proliferate at the wound site, helping create new tissue and extracellular matrix proteins, like collagen.
It increases the firmness of the skin by activating the extracellular matrix proteins synthesis such as collagen, elastin, fibronectin and laminin, according to the company.
We have been looking into stem cells as viable treatment options for correction of conditions such as epidermolysis bullosa, because they can produce extracellular matrix proteins.
When an organism suffers severe injury, specialized cells are "recruited" to the wound site that rapidly produce extracellular matrix proteins such as collagen to provide structural support to the tissue, explained Lester Lau, professor of biochemistry and molecular biology at the UIC College of Medicine and principal investigator in the study.
Phosphorylated Extracellular Matrix Proteins of Bone and Dentin is the second volume of the e-book series Frontiers between Science and Clinic in Odontology.
The research provides the first direct evidence that Granzyme B leads to chronic non-healing wounds through the degradation of extracellular matrix proteins that are required for wound healing.
Moreover, Cyclopeptide-5 is said to protect the extracellular matrix by down-regulating genes that stimulate degrading enzymes of extracellular matrix proteins such as collagenase 3 and elastase A2.

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