extracellular matrix

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extracellular matrix

the aggregate of proteins secreted by cells.

extracellular matrix

a substance containing collagen, elastin, proteoglycans, glycosaminoglycans, and fluid, produced by cells and in which the cells are embedded. The matrix secreted by chondroblasts, for example, is responsible for the properties of cartilage.

extracellular matrix

Non-living material secreted by cells that fills spaces between the cells in a tissue, protecting them and helping to hold them together. The extracellular matrix may be semifluid or rigidly solid and hard as in bone. It is composed mainly of protein and includes collagens, elastin, reticulin, glycoproteins, proteoglycans, fibronectin, laminins and osteopontin.

extracellular matrix (ECM)


extracellular matrix (eksˈ·tr·selˑ·y·ler māˑ·triks),

n substance produced by cells and secreted into the environment in which the cells are embedded; contains collagen, proteoglycans, glycosaminoglycans, and fluid; can influence the behavior of the cells. Also called
ECM. See also connective tissue.


situated or occurring outside a cell or cells.

extracellular constituents
all of the constituents of the body outside the cells; include water, electrolytes, protein, glucose, enzymes, hormones.
extracellular fluid
all of the body fluid lying outside the cells. Includes intravascular fluid or plasma and the interstitial fluid. That part of the extracellular fluid that is in special cavities which have special characteristics, e.g. synovial fluid, urine, aqueous humor of eye, are called transcellular fluids.
extracellular matrix
the network of proteins and carbohydrates that surround a cell or fill the intercellular spaces.
extracellular space
References in periodicals archive ?
Recently, LP has been mapped to chromosome 1q21, and the locus for the extracellular matrix protein 1(ECM1) gene and six different loss-of-function mutations in the ECM1 gene have been identified in patients affected by LP (2) Notably, the ECM1 gene product is an 85-kDa glycoprotein of unknown function that is believed to affect keratinocyte differentiation, and it is possible that it has a role in cell-cell adhesion (10).
In health, these cells are thought to play a role in extracellular matrix turnover via their ability to synthesize extracellular matrix proteins as well as matrix-degrading enzymes (matrix metallo-proteinases [MMPs]).
Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschsprung's disease.
CONCLUSIONS: These data demonstrate that the extracellular matrix protein mindin modifies the airway response to both LPS and ozone.
Comparative analysis of the expression of the extracellular matrix protein tenascin in normal human fetal, adult and tumor tissue.
Ascorbic acid has other properties that suggest it may be useful in treating rheumatoid arthritis: it is an antioxidant that scavenges ROS and it supports collagen formation and enhances extracellular matrix protein synthesis.
This accomplishment builds upon recently published work by Geron scientists which demonstrated the propagation of hESC lines in a new culture system containing exclusively, a single growth factor, a human extracellular matrix protein, and a defined cGMP medium containing no animal-derived materials.
The new culture system utilizes a single growth factor, a human extracellular matrix protein, and defined animal product-free medium manufactured under good manufacturing practice (cGMP) guidelines.
The new culture system utilizes a single recombinant human growth factor, a human extracellular matrix protein, and defined medium manufactured using current good manufacturing practices (cGMP).
The paper entitled "Neovascularization of Ischemic Tissues by Gene Delivery of the Extracellular Matrix Protein Del-1" is described in a press release from the University of California, San Diego ( http://cancer.
Patent and Trademark Office regarding three patents involving use of the extracellular matrix protein laminin-5 in the field of periodontal disease.
Desmos has succeeded in proliferating primary islet cells on the extracellular matrix protein laminin-5, and then reaggregating them to restore islet functionality.

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