The Mycotic Diseases Branch Laboratory at CDC confirmed the presence of Exserohilum rostratum
, an environmental mold and the primary pathogen in this outbreak, in lots 08 and 06 (3); detection of E.
Mold can even infect the central nervous system, often fatally, as occurred in a 2012 outbreak of meningitis from epidural injections contaminated by Exserohilum rostratum
It is, however, important to note that the fungal organism most commonly associated with fungal meningitis in the current outbreak, Exserohilum rostratum
, is currently uncharacterized relative to its contribution of (1,3)-b-D-glucan to the bloodstream.
Sealed vials of the steroid, made by the New England Compounding Center in Massachusetts, contained exserohilum rostratum
, a fungus found in soil and plants.
The CDC has confirmed that the fungus exserohilum rostratum
was present in at least 10 people stricken with the infection.
Effect of carbon sources on the production of extracellular cell wall degrading enzymes by Exserohilum rostratum
Food and Drug Administration announced today they had confirmed the presence of a fungus known as Exserohilum rostratum
in unopened vials of methylprednisolone acetate produced at New England Compounding Center.
These outbreaks of fungal infections are not the first associated with contaminated compounded products; they preceded (by only a few months) a large multistate outbreak of Exserohilum rostratum
infections associated with compounded methylprednisolone acetate (29).
Conversely, recent contamination of a widely distributed injectable steroid medication with fungal organisms, particularly the black mold Exserohilum rostratum
, caused the largest health care-associated outbreak in the United States; as of July 1, 2013, there have been 749 cases of meningitis and related infections among persons in 20 states and 61 deaths (10,11).
The effect of different carbon sources on the production of extracellular pectinases of Exserohilum rostratum was investigated.
Exserohilum rostratum (Dreschler) Leonard & Suggs (Leonard and Suggs, 1974), attacks many gramineous species of plants, including some hosts of economic importance.
The extracellular cellulases of Exserohilum rostratum
and the effect of different carbon sources on the production of these enzymes were investigated.