exonuclease

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exonuclease

 [ek″so-noo´kle-ās]
an enzyme that cleaves single mononucleotides from the end of a polynucleotide chain.

ex·o·nu·cle·ase

(ek'sō-nū'klē-ās),
A nuclease that releases one nucleotide at a time, serially, beginning at one end of a polynucleotide (nucleic acid); several have been prepared from Escherichia coli, designated exonuclease I, exonuclease II, etc.; exonuclease III, which removes nucleotides from 3' ends of DNA, is used in DNA sequencing. Compare: endonuclease.

exonuclease

/exo·nu·cle·ase/ (ek″so-noo´kle-ās) any nuclease specifically catalyzing the hydrolysis of terminal bonds of deoxyribonucleotide or ribonucleotide chains, releasing mononucleotides.

exonuclease

(ĕk′sō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
n.
Any of a group of enzymes that catalyze the hydrolysis of single nucleotides from the end of a DNA or RNA chain.

exonuclease

[ek′sōno̅o̅′klē·ās]
Etymology: Gk, exo + L, nucleus, nut; ase, enzyme
an enzyme that digests DNA or RNA from the ends of the strands. Compare endonuclease.

ex·o·nu·cle·ase

(eks'ō-nū'klē-ās)
A nuclease that releases one nucleotide at a time, serially, beginning at one end of a polynucleotide (nucleic acid).
Compare: endonuclease

exonuclease

an enzyme that removes a terminal NUCLEOTIDE (3' or 5') in a POLYNUCLEOTIDE CHAIN. Exonucleases remove the nucleotides in a successive way, one by one, and are highly specific in their action.

ex·o·nu·cle·ase

(eks'ō-nū'klē-ās)
A nuclease that releases one nucleotide at a time, serially, beginning at one end of a polynucleotide (nucleic acid).
Compare: endonuclease

exonuclease

a nuclease that cleaves single mononucleotides from the end of a polynucleotide chain.

exonuclease III
one from E. coli that removes nucleotides from the 3′ ends of double-stranded DNA.
References in periodicals archive ?
Exonuclease III and Fpg nucleases recognize and cut the internal abasic residue, thus generating fluorescence.
Competitor cDNA was generated by deletion using exonuclease III as described previously by our laboratory (21).