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excitotoxicity |
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excitotoxicity exaggerated and continuous stimulation by a neurotransmitter, especially in those neuronal systems which use glutamate as the transmitter. excitotoxicity Neurology Neuronal injury caused by excessive release of excitatory neurotransmitters–glutamate and aspartate causing damage to nerve and glial cells, which occurs in diverse neurologic diseases that may be acute–eg
hypoglycemia, seizures, stroke, or trauma or chronic neurodegenerative disease–eg AIDS-dementia complex, amyotrophic lateral sclerosis, Huntington's disease, and possibly Alzheimer's disease |
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Estrogens attenuate and corticosteroid exacerbates exitotoxicity, oxidative injury and amyloid B-peptide toxicity in hippocampal neurons. |
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