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stress ulcer |
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ulcer /ul·cer/ (ul´ser) a local defect, or excavation of the surface, of an organ or tissue, produced by sloughing of necrotic inflammatory tissue. corneal ulcer ulcerative keratitis. decubital ulcer , decubitus ulcer bedsore; an ulceration due to an arterial occlusion or prolonged pressure, as when a patient is confined to a bed or a wheelchair. duodenal ulcer a peptic ulcer situated in the duodenum. gastric ulcer an ulcer of the gastric mucosa. Hunner's ulcer one involving all layers of the bladder wall, occurring in chronic interstitial cystitis. jejunal ulcer an ulcer of the jejunum; such an ulcer following surgery is called a secondary jejunal u. marginal ulcer a gastric ulcer in the jejunal mucosa near the site of a gastrojejunostomy. peptic ulcer an ulceration of the mucous membrane of the esophagus, stomach, or duodenum, due to action of the acid gastric juice. perforating ulcer one involving the entire thickness of an organ or of the wall of an organ creating an opening on both surfaces. phagedenic ulcer 1. a necrotic lesion associated with prominent tissue destruction, due to secondary bacterial invasion of an existing cutaneous lesion or of intact skin in a person with impaired resistance as the result of systemic disease. plantar ulcer a deep neurotrophic ulcer of the sole of the foot, resulting from repeated injury because of lack of sensation in the part; seen with diseases such as diabetes mellitus and leprosy. rodent ulcer ulcerating basal cell carcinoma of the skin. stercoraceous ulcer , stercoral ulcer one caused by pressure of impacted feces; also, a fistulous ulcer through which fecal matter escapes. stress ulcer peptic ulcer, usually gastric, resulting from stress. trophic ulcer one due to imperfect nutrition of the part. tropical ulcer 1. a lesion of cutaneous leishmaniasis. tropical phagedenic ulcer a chronic, painful, phagedenic ulcer of unknown cause, usually on the lower limbs of malnourished children in the tropics. varicose ulcer an ulcer due to varicose veins. venereal ulcer a nonspecific term referring to the formation of ulcers resembling chancre or chancroid about the external genitalia. stress ulcer, a gastric or duodenal ulcer that develops in previously unaffected individuals subjected to severe stress, such as a severe burn. See also Curling's ulcer. ulcer a local defect, or excavation of the surface of an organ or tissue, produced by sloughing of necrotic inflammatory tissue. They occur in all organs and tissues and are to be found under those headings, e.g. abomasal, corneal, gastric. button ulcer see button ulcer. callous ulcer see set-fast (2). collagenase ulcer a rapidly expanding, erosive ('melting') corneal ulcer, seen particularly in brachycephalic breeds of dogs. Curling's ulcer acute ulceration of the stomach or duodenum seen after severe burns of the body in humans. decubitus ulcer see decubitus ulcer. dendritic ulcer linear, branching pattern of ulceration on the cornea; characteristic of herpesvirus infections. See also herpetic keratitis. eosinophilic ulcer see eosinophilic ulcer. gastroduodenal ulcer geographic ulcer a large, superficial, irregularly shaped corneal ulcer, typically formed by the coalescence of several dendritic ulcers. indolent ulcer see eosinophilic ulcer, refractory ulcer (below). infectious dermal ulcer a systemic, fatal bacteremia of snakes manifested by multiple, small cutaneous ulcers. Called also scale rot. intestinal ulcer is rare in all species. When they do occur, intestinal ulcers usually cause signs of chronic enteritis. It is a common lesion in adenocarcinoma of the intestine. See also peptic ulcer. lip ulcer see eosinophilic ulcer. lip and leg ulcer see ulcerative dermatosis. melting ulcer see collagenase ulcer (above). ulcer mound a gastric ulcer viewed tangentially radiographically creates a mound in the otherwise smooth outline of radiopaque material in the stomach. necrotic ulcer of swine see ulcerative granuloma of swine. perforating ulcer one that involves the entire thickness of an organ, creating an opening on both surfaces. See also ulcer perforation. phagedenic ulcer a necrotizing lesion in which tissue destruction is prominent. refractory ulcer a chronic, superficial corneal ulceration in dogs, particularly common in Boxers, that extends into the superficial stroma, often undermining epithelium at the edges. The cause is unknown but abnormalities of the basal epithelial cells and anterior stroma have been noted. Response to the usual methods of treatment for corneal ulceration is characteristically very slow; superficial keratectomy is the treatment of choice. Called also superficial corneal erosion syndrome, Boxer ulcer. rodent ulcer see eosinophilic ulcer. stress ulcer superficial ulcerations or erosions of mucosa in the stomach, duodenum or colon. The possible predisposing factors include changes in the microcirculation of the gastric mucosa, increased permeability of the gastric mucosa barrier to H+, and impaired cell proliferation. stromal ulcer a corneal ulcer involving the stroma. trophic ulcer one due to imperfect nutrition of the part. In dogs, may develop in digital and metatarsal pads in association with tibial nerve injury. stress ulcer Stress ulceration GI disease An erosion of the gastric mucosa, attributed to physical or mental stress Risk factors Respiratory failure, coagulopathy Management Ranitidine. See Executive monkey, Ranitidine, 'Toxic
core, ' Type A personality. Cf Sucralfate.
Stress ulcer types*
Activity ulcer A type of gastric erosion produced when rats are placed in a running wheel with access to food for only 1 hr/day
Exertion ulcer Gastric ulceration that is associated with excessive and unexpected forced activity, eg a rotating cage keeps the rodents constantly running and the gastric juices flowing to the maximum
Restraint ulcer An ulcer that appears in rats hours after placement in a very confined spaces, especially when the ambient temperature is lowered
Shock ulcer Gastric ulcer in humans related to burns, eg Curling's ulcer, ischemia, neurologic injury, eg Cushing's ulcer, sepsis or trauma
*Given the association of gastric ulcers with H pylori; many respond to antibiotics; because bleeding from SUs is relatively rare, but has a high mortality–in one report, 49% vs 9% without hemorrhage, the use of prophylactic measures,
eg neutralization of gastric acid, ↓ gastric acid secretion and cytoprotection is commonly recommended; prophylaxis is best administered to those at highest risk–respiratory failure-odds ratio 15.6, coagulopathy-odds ratio 4.3) for GI
bleeding and can be withheld from other Pts–NEJM 1994; 330:377oa
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