excitotoxin


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excitotoxin

(ĭk-sī′tə-tŏk′sĭn)
n.
Any of a group of neurologically active compounds, including glutamate and aspartame, that in high concentrations have detrimental excitatory effects on the central nervous system and may cause injury to nerve cells.

ex·ci′to·tox′ic (ĭk-sī′tə-tŏk′sĭk) adj.

excitotoxin

(ĕk-sī″tō-tŏks′ĭn)
A neurotransmitter (e.g., glutamate or aspartate) that can cause brain cell injury or death if its action is unabated. Brain damage is mediated by excitotoxins during prolonged seizure activity and stroke.
References in periodicals archive ?
Brain cells that are low in magnesium are particularly sensitive to the damaging effects of excitotoxins like aspartame.
Blaylock shows how these excitotoxins can affect a developing brain.
Martin now plans to survey the distribution of excitotoxin receptors in the brain, to see if the NMDA receptro-Huntington's link holds up.
Renewal of an NIH grant of $749,000 to allow the completion of pre-clinical work on a series of glial excitotoxin release inhibitors.
Quinolinic acid induced brain neurotransmitter deficits; modulation by endogenous excitotoxin antagonists.
Inducing hypothermia by lowering the patient's core temperature acts to reduce secondary brain injury by suppressing excitotoxin and free-radical reactions, stabilizing cell membranes, reducing intracellular acidosis, and reducing abnormal electrical activity (Kabon, Bacher, & Spiss, 2003).
AMEX:QSC) announced today that the National Institutes of Health (NIH) notified Questcor of the renewal of an SBIR grant for further research on its series of glial excitotoxin release inhibitors (GERI) compounds.
The animals were treated with kainic acid, an excitotoxin known to induce recurrent seizures, and either EUK-134 or saline.
The Cypros compounds being supported by the grant are high potency inhibitors of swelling-induced, excitotoxin release from glial cells and have been shown to be effective in pre-clinical models of stroke.
Geier, MD, PhD, president of the Genetic Centers of America, says that vaccines contain many potentially harmful ingredients: human albumen, the excitotoxin MSG, bovine serum, hamster ovary cells, monkey kidney tissue, formaldehyde, aluminum hydroxide, and thimerosal.
Similarly, the concentration of glutamic acid decarboxylase (GAD), which converts the excitotoxin glutamate to GABA, has been found to be decreased in numerous studies.
Monosodium glutamate (MSG) is another toxic chemical and an excitotoxin, as it is able to "overstimulate cells to death.